Robert Sean Leonard, who portrays Wilson, said that House and his character—whose name is very similar to Watson's—were originally intended to work together much as Holmes and Watson do; in his view, House's diagnostic team has assumed that aspect of the Watson role.
Individual episodes of the series contain additional references to the Sherlock Holmes tales.
Paul Attanasio and Katie Jacobs, the heads of Heel and Toe Films; David Shore, the head of Shore Z Productions; and Bryan Singer, the head of Bad Hat Harry Productions, were executive producers of the program for its entirety. Moran joined the staff as writers at the beginning of the first season after the making of the pilot episode.
Writers Doris Egan, Sara Hess, Russel Friend, and Garrett Lerner joined the team at the start of season two.
As a cost-cutting measure, the three actors were asked to accept reduced salaries.
Epps and Leonard came to terms with the producers, but Edelstein did not, and in May 2011 it was announced that she would not be returning for the show's eighth season.
Of the more than three dozen other directors who have worked on the series, only David Straiton directed as many as 10 episodes through the sixth season.
While Penn and Wilde had higher profiles than the actors who played the other finalists, Jacobs said they went through an identical audition process and stayed with the show based on the writers' interest in their characters.
The contracts of Edelstein, Epps, and Leonard expired at the end of season seven.
House's head then fades and the show's title is underlined and has the "M.
D." appear next to it, producing the entire logo of the show.